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Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves.

J. Lipid Res. 2008 Jul;49(7):1511-8.
PubMed Citation Journal Link

The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we inve...ol contents in stenotic aortic valves. These findings suggest that local accumulation of plant sterols and cholesterol precursors may participate in the pathobiology of aortic valve disease.

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