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Comparison of transdermal to oral estradiol administration on hormonal and hepatic parameters in women with premature ovarian failure.

J. Clin. Endocrinol. Metab. 1991 Aug;73(2):275-80.
PubMed Citation Journal Link

Five women with premature ovarian failure were studied in a randomized cross-over design to compare the biochemical effects of transdermal to oral estradiol administration when used in doses...hormonally normal cycle, the transdermal route did not significantly alter the hepatic parameters studied, suggesting that this route of administration may have less adverse hepatic effects.

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