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Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation.

Am. J. Physiol. Renal Physiol. 2009 May;296(5):F1146-57.
PubMed Citation Journal Link

TNF-alpha and NF-kappaB play important roles in the development of inflammation in chronic renal failure (CRF). In hepatic cells, curcumin is shown to antagonize TNF-alpha-elicited NF-kappaB...PARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.

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