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Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells.

J. Lipid Res. 2009 May 21.
PubMed Citation Journal Link

Inhibitors of HMG-CoA reductase (statins) are widely used medications for reduction of cholesterol levels. Statin use significantly reduces risk of cardiovascular disease, but has also been ... suggest that simvastatin and pravastatin differentially affect expression of genes involved in neurodegeneration, and that statin-dependent gene expression regulation is cell-type specific.

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