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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

Diabetes 2002 Oct;51(10):2944-50.
PubMed Citation Journal Link

Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulati...from lean volunteers (P < 0.01). We conclude that there is an impaired bioenergetic capacity of skeletal muscle mitochondria in type 2 diabetes, with some impairment also present in obesity.

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