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Effect of a high dose of simvastatin on muscle mitochondrial metabolism and calcium signaling in healthy volunteers.

Toxicology and applied pharmacology 2012 Jul 3.
PubMed Citation Journal Link

Statin use may be limited by muscle side effects. Although incompletely understood to date, their pathophysiology may involve oxidative stress and impairments of mitochondrial function and o...that statin induced muscular toxicity may be related to alterations in mitochondrial respiration and muscle calcium homeostasis independently of underlying disease or concomitant medication.

1 Analysis

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Muscle on the elderly

Conditioning Research
July 10, 2012
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