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Effects of intensive glucose lowering in type 2 diabetes.

N. Engl. J. Med. 2008 Jun 12;358(24):2545-59.
PubMed Citation Journal Link

... CONCLUSIONS: As compared with standard therapy, the use of intensive therapy to target normal glycated hemoglobin levels for 3.5 years increased mortality and did not significantly reduce major cardiovascular events. These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)

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