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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

Nat. Immunol. 2011 May;12(5):408-15.
PubMed Citation Journal Link

High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1? plays a role in insulin resistance, yet how IL-1? is induced by...rmore, IL-1? affects insulin sensitivity through tumor necrosis factor-independent and dependent pathways. These findings provide insights into the association of inflammation, diet and T2D.

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