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Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans.

Circulation 2009 Aug 3.
PubMed Citation Journal Link

BACKGROUND: -Mutations in the LCAT gene cause lecithin:cholesterol acyltransferase (LCAT) deficiency, a very rare metabolic disorder with 2 hypoalphalipoproteinemia syndromes: classic famili...the notion that LCAT is required for effective atheroprotection and suggests that elevating LCAT expression or activity is not a promising therapeutic strategy to reduce cardiovascular risk.

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