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High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.

J. Biol. Chem. 2007 Aug 10;282(32):23672-8.
PubMed Citation Journal Link

Liver-specific insulin receptor knock-out (LIRKO) mice display hyperinsulinemia, abnormal glucose metabolism, and progressive liver dysfunction. In addition, circulating leptin levels appear...nhibit leptin action and may actually potentiate leptin action. In this manner, insulin signaling in liver plays an important role in leptin homeostasis and fine modulation of leptin action.

2 Analyses


LIRKO mice (2)

May 15, 2011

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The Daily Lipid
November 18, 2010
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