Paleo for Life Logo

Our mission is to improve people's health and eliminate chronic diseases by sharing the wisdom of the Paleo diet and lifestyle.

If the Paleo lifestyle has made a positive difference in your health, help spread the word. We can influence the world through our collective voices.

Facebook Fan Page

Share |

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.

Hepatology 2010 Sep;52(3):934-44.
PubMed Citation Journal Link

... CONCLUSION: These findings demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis. Plasma (ox)CoQ9 correlated with fibrosis progression. The mechanism of fibrosis may involve fructose inducing increased ROS associated with CD11b+F4/80+Gr1+ hepatic macrophage aggregation, resulting in transforming growth factor beta1-signaled collagen deposition and histologically visible hepatic fibrosis.

Community Experience

Paleo Diet for Hepatitis
1 review
Paleo Diet for Obesity
0 reviews
Paleo Diet for Weight Loss
12 reviews

2 Analyses


Fathead Supersize Me and Sweden (2)

September 18, 2010

Fathead, Supersize Me and Sweden

September 16, 2010
Copyright © 2020 Enacct Systems LLC. All rights reserved.
User contributed content licensed under the Creative Commons Attribution-Share Alike 3.0 Unported License with attribution required.
Paleo for Life does not provide medical advice, diagnosis or treatment. All content is for informational purposes only.
Get detailed food nutrient information at Chowstat Nutrition Facts.