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Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.

Obes. Res. 2005 Aug;13(8):1476-84.
PubMed Citation Journal Link

OBJECTIVE: The term metabolic syndrome (MS) describes a cluster of cardiovascular risk factors including dyslipidemia, glucose intolerance, insulin resistance, and hypertension. Obesity incr...ated to the development of glucose intolerance and insulin resistance. The extent to which these relationships are explained through residual confounding by obesity remains to be determined.

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