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Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.

J. Clin. Invest. 2008 Jul;118(7):2583-91.
PubMed Citation Journal Link

Increased hunger and food intake during attempts to maintain weight loss are a critical problem in clinical management of obesity. To determine whether reduced body weight maintenance is acc...response to food cues in the hypothalamus, cingulate gyrus, and middle frontal gyrus. These data are consistent with a model of the weight-reduced state as one of relative leptin deficiency.

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