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Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs.

J. Orthop. Res. 2011 Nov 4.
PubMed Citation Journal Link

Histological and molecular changes were examined to investigate the effects of long-term administration of glucosamine (GlcN) and chondroitin sulfate (CS) in a model of spontaneous osteoarth...n, maintains total RNA and down-regulates MMP-3 mRNA in a spontaneous OA model in Hartley guinea pigs. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

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