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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Mol. Cell 2000 Jul;6(1):87-97.
PubMed Citation Journal Link

The liver plays a central role in the control of glucose homeostasis and is subject to complex regulation by substrates, insulin, and other hormones. To investigate the effect of the loss of...d functional changes, and the metabolic phenotype becomes less severe. Thus, insulin signaling in liver is critical in regulating glucose homeostasis and maintaining normal hepatic function.

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