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Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.

Cell 2012 Oct 12;151(2):400-13.
PubMed Citation Journal Link

Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT). Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the c...nt mechanism of transmembrane H(+) transport may be employed by other SLC25 members and be responsible for mitochondrial uncoupling and regulation of metabolic efficiency in various tissues.

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