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Metabolic syndrome: comparison of the two commonly used animal models.

Am. J. Hypertens. 2008 Sep;21(9):1018-22.
PubMed Citation Journal Link

... CONCLUSIONS: The fructose-fed SDR model represents a predominantly environmentally acquired MS, whereas the SHR model is less affected by dietary intervention and better displays the predominantly genetic spontaneous appearance of the syndrome. This fundamental difference should be taken into consideration when choosing an animal model to study the MS.

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