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Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesis.
Cardiology 2005;103(3):137-41.
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It is now widely accepted that oxidant stress and the ensuing endothelial dysfunction play a key role in the pathogenesis of atherosclerosis and cardiovascular diseases. The mitochondrial re...for atherosclerosis. We propose that mitochondrial dysfunction, besides endothelial dysfunction, represents an important early step in the chain of events leading to atherosclerotic disease.
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