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Mitonuclear match: optimizing fitness and fertility over generations drives ageing within generations.

Bioessays 2011 Nov;33(11):860-9.
PubMed Citation Journal Link

Many conserved eukaryotic traits, including apoptosis, two sexes, speciation and ageing, can be causally linked to a bioenergetic requirement for mitochondrial genes. Mitochondrial genes enc...sses also operate within generations, driving ageing and age-related diseases. This coherent view of eukaryotic energetics offers striking insights into infertility and age-related diseases.

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