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Role of brain insulin receptor in control of body weight and reproduction.

Science 2000 Sep 22;289(5487):2122-5.
PubMed Citation Journal Link

Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the central nervous system (CNS). To study the physiological role of insulin signaling in the brain, ...ation because of hypothalamic dysregulation of luteinizing hormone. Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction.

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