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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

Endocrinology 2003 Sep;144(9):4154-63.
PubMed Citation Journal Link

We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet beta-cell damage because high gluco...ctivating fatty acid oxidation. The results support the glucolipotoxicity hypothesis of beta-cell failure proposing that elevated FFAs are particularly toxic in the context of hyperglycemia.

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