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Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis.

JAMA 2007 Feb 7;297(5):499-508.
PubMed Citation Journal Link

... CONCLUSIONS: Statin therapy is associated with regression of coronary atherosclerosis when LDL-C is substantially reduced and HDL-C is increased by more than 7.5%. These findings suggest that statin benefits are derived from both reductions in atherogenic lipoprotein levels and increases in HDL-C, although it remains to be determined whether the atherosclerotic regression associated with these changes in lipid levels will translate to meaningful reductions in clinical events and improved clinical outcomes.

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