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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

Diabetes 2010 Feb;59(2):479-85.
PubMed Citation Journal Link

... CONCLUSIONS: The TCF7L2 variant rs7903146 appears to affect risk of type 2 diabetes, at least in part, by modifying the effect of incretins on insulin secretion. This is not due to reduced secretion of GLP-1 and GIP but rather due to the effect of TCF7L2 on the sensitivity of the beta-cell to incretins. Treatments that increase incretin sensitivity may decrease the risk of type 2 diabetes.

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