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The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

J. Clin. Invest. 1997 Jul 15;100(2):398-403.
PubMed Citation Journal Link

Lowering of the elevated plasma FFA concentration in 18- 24-h fasted rats with nicotinic acid (NA) caused complete ablation of subsequent glucose-stimulated insulin secretion (GSIS). Althoug...s FFA pool. Both factors will likely be important considerations in understanding the complex interplay between the nature of dietary fat and whole body insulin, glucose, and lipid dynamics.

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