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Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms.

Ann. N. Y. Acad. Sci. 2009 May;1165:195-205.
PubMed Citation Journal Link

Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on celiac disease (CD),...e that besides genetic and environmental factors, loss of intestinal barrier function is necessary to develop autoimmunity. In this review, each of these components will be briefly reviewed.

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